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Common Side Effects Returns: The Animated Thriller That’s Changing Adult Animation!

by Thabasum Shaik Editor
April 1, 2025
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“Common Side Effects Season 2: The Trippy Animated Thriller That’s Taking Over Adult Swim!”

From Joe Bennett (Scavengers Reign) and Steve Hely (Veep), along with executive producers Mike Judge and Greg Daniels (King of the Hill), Common Side Effects is officially coming back for a second season on Adult Swim! This darkly comedic animated thriller follows the chaos that unfolds after the discovery of a mysterious, all-healing mushroom.

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A Groundbreaking Show Gets a Well-Deserved Renewal

“Joe and Steve did their job by crafting a boundary-pushing and genre-defining piece of television that re-frames what ‘adult animation’ is capable of,” said Adult Swim President Michael Ouweleen. “And you all did your job by showing up on Adult Swim and Max to support the show and lighting up your socials to spread the word. So, see? We can have nice things.”

Clearly, the fans have spoken—this show is a hit!

The Premise: A Mushroom That Could Change the World

At the heart of Common Side Effects is a wild premise: Marshall and Frances, two former high school lab partners, stumble upon the ultimate game-changer—a mushroom that can heal almost anything. But, of course, nothing this good comes without consequences. Their discovery puts them in the crosshairs of powerful enemies, including the DEA, big pharma, and international businessmen, all determined to shut them down before they can unleash their medical miracle on the world.

The Creators’ Vision

The creators are just as thrilled as the fans.

“We are grateful for the enthusiastic response to Common Side Effects and are thrilled to continue exploring this world with our amazing team and the fans who have embraced the show,” said co-creators Bennett and Hely. “The opportunity to push the boundaries of animation and storytelling on Adult Swim is like a wonderful mushroom dream. Our goal with the show is to transform planet Earth and restore the human spirit. For now, we will settle for a second season.”

Talk about ambition! But if season one is anything to go by, these guys might just pull it off.

The Star-Studded Cast & Production Team

The show boasts an impressive voice cast, featuring Joseph Lee Anderson, Mike Judge, Martha Kelly, Dave King, and Emily Pendergast. Behind the scenes, Common Side Effects is produced by Bandera Entertainment and Green Street Pictures, ensuring top-tier animation and storytelling.

Season Finale & What’s Next

If you haven’t caught up yet, don’t miss the season one finale airing this Sunday at 11:30 p.m. ET/PT on Adult Swim. With a second season now confirmed, there’s no better time to jump into the wild, unpredictable world of Common Side Effects.

Are you excited for more? Let us know what you think of this mind-bending animated thriller!

Thabasum Shaik Editor

Thabasum Shaik Editor

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