Aliens, Fame & Cyborg Scandals: Prime Video’s wildest sci-fi comedy returns May 27!
Pack your stethoscopes and fasten your intergalactic seatbelts—Prime Video is taking us back to the cosmos with the return of its hilariously chaotic adult animated comedy, The Second Best Hospital in the Galaxy. The highly anticipated second season blasts off on Tuesday, May 27, with all eight episodes dropping worldwide in over 240 countries and territories. That’s right, the galaxy is getting weird (again), and you won’t want to miss a second.
In Case You Missed Season 1
This isn’t your average ER. Think Grey’s Anatomy meets Rick and Morty, with a dash of cosmic absurdity. Created by Cirocco Dunlap and executive produced by comedy legends Maya Rudolph and Natasha Lyonne, the series follows two space-surgeons—Dr. Sleech and Dr. Klak—who perform dangerously groundbreaking surgeries while navigating bizarre alien ailments, friendship drama, and galactic fame.
Season 2: When Success Gets… Messy
Our favorite duo, Sleech and Klak, are riding high after a (probably illegal) miracle medical breakthrough. But Season 2 throws a wrench in their cosmic routine with the arrival of a nosy cyborg journalist determined to dig up Sleech’s past. Klak? She’s just trying to keep the good times rolling. Fame, as it turns out, comes with side effects.
Expect more daring diagnoses, more cosmic body horror (you’ve been warned), and plenty of existential crises—all wrapped in a wildly entertaining eight-episode binge.
Voice Cast That’s Out of This World
This season features a galaxy of stars: Stephanie Hsu (Everything Everywhere All At Once), Keke Palmer, Kieran Culkin (Succession), Sam Smith, Maya Rudolph, and Natasha Lyonne. Comedy favorites like Abbi Jacobson, Bowen Yang, Andrew Dismukes, and John Waters round out the cast with energy and charm that match the show’s offbeat tone.
Behind the Space Scenes
Cirocco Dunlap returns as writer, showrunner, and executive producer, joined by Rudolph and Lyonne under their Animal Pictures banner. Animation is handled by Titmouse—the team behind Big Mouth and Star Trek: Lower Decks—with dreamy neon visuals from production designer Robin Eisenberg, whose unique aesthetic brings this chaotic cosmos to life.
Why You Should Watch
Beneath the alien parasites and black hole surgeries, this show has real emotional stakes. It’s a blend of absurdist sci-fi and grounded themes of friendship, ambition, and vulnerability. It’s chaotic, it’s heartfelt—and it’s hilarious.
So whether you’re a returning fan or new to the galaxy, The Second Best Hospital in the Galaxy promises a binge-worthy ride that’s both bizarre and beautiful.
Final Diagnosis: Must-Watch
Season 2 drops May 27 exclusively on Prime Video. If Season 1 was any indication, you’ll want front-row seats for this cosmic medical meltdown. Brain transplants, body swaps, and zero-gravity breakdowns await—Dr. Sleech and Dr. Klak are ready to scrub in. Are you?
